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Publications

2013
Chen XL, Serrano D, Mayhue M, Wieden H-J, Stankova J, Boulay G, Ilangumaran S, Ramanathan S. GTPase of the immune-associated nucleotide-binding protein 5 (GIMAP5) regulates calcium influx in T-lymphocytes by promoting mitochondrial calcium accumulation. Biochem J. 2013;449(2):353-364.
2012
Becker M, Gzyl K, A.M. A, Vuong A, Urban K, Wieden H-J. The 70S ribosome modulates the ATPase activity of Escherichia coli YchF. RNA Biology . 2012;9(10):1288-1301.
Fischer JJ, Coatham ML, Eagle Bear S, Brandon HE, De Laurentiis EI, Shields MJ, Wieden H-J. The ribosome modulates the structural dynamics of the conserved GTPase HflX and triggers tight nucleotide binding. Biochimie. 2012;94(8):1647-1659.
Gruninger RJ, Dobing S, Smith AD, Bruder LM, Selinger LB, Wieden H-J, Mosimann SC. Substrate binding in protein tyrosine phosphatase-like inositol polyphosphatases. J. Biol. Chem . 2012;287(13):9722-9730.
2011
De Laurentiis EI, Mo F, Wieden H-J. Construction of a fully active Cys-less Elongation Factor Tu: Functional role of the conserved Cystein 81. Biochim. Biophys. Acta. 2011;1814:684-692.
2010
Wieden H-J, Mercier E, Gray J, Steed B, Yawney D. A combined molecular dynamics and rapid kinetics approach to identify conserved 3 dimensional communication networks in Elongation Factor Tu. Biophys J. 2010;99:3735-3743.
2009
Shields M, Fischer JJ, Wieden H-J. Toward understanding the function of the universally conserved GTPase HflX from Escherichia coli: A kinetic approach. Biochemistry. 2009;48:10793-10802.
2006
Dahl LD, Wieden H-J, Rodnina MV, Knudsen CR. The importance of P-loop and domain movements in EF-Tu for guanine nucleotide exchange. J. Biol. Chem . 2006;281:21139-21146.
2005
Buskiewicz I, Peske F, Wieden H-J, Gryczynski I, Rodnina MV, Wintermeyer W. Conformations of the Signal Recognition Particle Protein Ffh from Escherichia coli as Determined by FRET. J. Mol. Biol. 2005;351:417-430.
Rodnina MV, Gromadski KB, Kothe U, Wieden H-J. Recognition and selection of tRNA in translation. FEBS Lett. 2005;579:938-942.
2004
Kothe U, Wieden H-J, Mohr D, Rodnina MV. Interaction of helix D of elongation factor Tu with helices 4 and 5 of protein L7/12 on the ribosome. J Mol Biol. 2004;336:1011-1021.
2003
Juranek S, Wieden H-J, Lipps HJ. De novo cytosine methylation in the differentiating macronucleus of the stichotrichous ciliate Stylonychia lemnae. Nuc. Acids Res. 2003;31:1387-1391.
Daviter T, Wieden H-J, Rodnina MV. Essential role of histidine 84 in elongation factor Tu for the chemical step of GTP hydrolysis on the ribosome. J. Mol. Biol. 2003;332:689-699.
Gu S-Q, Peske F, Wieden H-J, Rodnina MV, Wintermeyer W. The signal recognition particle binds to protein L23 at the peptide exit of the E. coli ribosome. RNA. 2003;9:566-573.
2002
Schirmer J, Wieden H-J, Rodnina MV, Aktories K. Inactivation of the elongation factor Tu by mosquitocidal toxin catalyzed mono-ADP-ribosylation. Appl. Environ. Microbiol. 2002;68:4894-4899.
Gromadski KB, Wieden H-J, Rodnina MV. Kinetic mechanism of elongation factor Ts-catalyzed nucleotide exchange in elongation factor Tu. Biochemistry. 2002;41:162-169.
Wieden H-J, Gromadski KB, Rodnin DN, Rodnina MV. Mechanism of EF-Ts-catalzed nucleotide exchange in EF-Tu: Contribution of contacts at the guanine base. J. Biol. Chem . 2002;277:6032-6036.
Stark H, Rodnina MV, Wieden H-J, Zemlin F, Wintermeyer W, van Heel M. Ribosome interactions of aminoacyl-tRNA and elongation factor Tu in the codon recognition complex. Nat. Struct. Biol. 2002;9:849-854.
2001
Wieden H-J, Wintermeyer W, Rodnina MV. A common structural motif in elongation factor Ts and ribosomal protein L7/12 may be involved in the interaction with elongation factor Tu. J. Mol. Evol. 2001;52:129-136.
Knudsen CR, Wieden H-J, Rodnina MV. Importance of structural transitions of the switch II region for the functions of elongation factor Tu on the ribosome. J. Biol. Chem . 2001;276:22183-22190.
Stark H, Rodnina MV, Wieden H-J, van Heel M, Wintermeyer W. Large-scale movement of elongation factor G and extensive conformational changes of the ribosome during translocation. Cell. 2001;100:301-309.
2000
Rodnina MV, Stark H, Savelsbergh A, Wieden H-J, Mohr D, Matassova NB, Peske F, Daviter T, Gualerzi CO, Wintermeyer W. GTPase mechanisms and functions of translation factors on the ribosome. Biol. Chem. 2000;381:377-387.