Publications

2017
Rintala-Dempsey A, Kothe U. Eukaryotic stand-alone pseudouridine synthases - RNA modifying enzymes and emerging regulators of gene expression?. RNA Biology. 2017;Jan 3:1-12:epub ahead of print.
2016
Keffer-Wilkes L, Veerareddygari GR, Kothe U. RNA modification enzyme TruB is a tRNA chaperone. PNAS. 2016;113:14306 – 14311.
2015
Tillault AS, Fourmann JB, Loegler C, Wieden HJ, Kothe U, Charpentier B. Contribution of two conserved histidines to the dual activity of archaeal RNA guide-dependent and -independent pseudouridine synthase Cbf5. RNA. 2015;accepted.
2013
Kamalampeta R, et al. tRNA binding, positioning and modification by the pseudouridine synthase Pus10. JMB. 2013;425(25):3863-3974.
2012
Kamalampeta R, Kothe U. Archaeal proteins Nop10 and Gar1 increase the catalytic activity of Cbf5 in pseudouridylating tRNA. Scientific Reports. 2012;2(663):DOI: 10.1038/srep00663.
Kothe U. New frontiers in studying pseudouridine formation in RNA. Cell News. 2012;2:48-56. kothecellnews_02_2012.pdf
2010
Kothe U. Recent Progress on Understanding Ribosomal Protein Synthesis. In: Comprehensive Natural Products II Chemistry and Biology, Section Amino Acids, Peptides and Proteins. Oxford: Elsevier; 2010.
2007
Kothe U, Rodnina MV. Codon reading by tRNAAla with modified uridine in the wobble position. Molecular Cell. 2007;25(1):167-174.
2006
Kothe U, Rodnina MV. Delayed release of inorganic phosphate from elongation factor Tu following GTP hydrolysis on the ribosome. Biochemistry. 2006;45:12767-12774.
Kothe U, Paleskava L, Konevega AL, Rodnina MV. Single-step purification of specific tRNAs by hydrophobic tagging. Analtyical Biochemistry. 2006;356:148-150.
2005
Savelsbergh A, Mohr D, Kothe U, Wintermeyer W, Rodnina MV. Control of Phosphate Release from Elongation Factor G by Ribosomal Protein L7/12. EMBO Journal. 2005;24(24):4316-4323.
Diaconu M, Kothe U, Schluenzen F, Fischer N, Harms J, Tonevitski AG, Stark H, Rodnina MV, Wahl MC. Structural basis for the Function of the Ribosomal L7/12 Stalk in Factor Binding and Activation of GTP Hydrolysis. Cell. 2005;121(7):991-1004.
2004
Kothe U, Wieden H-J, Mohr D, Rodnina MV. Interaction of Helix D of Elongation Factor Tu with Helices 4 and 5 of Protein L7/12 on the Ribosome. Journal of Molecular Biology. 2004;336:1011-1021.